Hong Kong Genome Institute 香港基因組中心

【Latest Research in Nature Medicine: Advancing Precision Medicine for Chinese Populations】 We are excited to share that our research paper, “Population-scale genomic medicine with the Hong Kong Genome Project”, has been published in Nature Medicine. The study's significance was highlighted by the Nature Medicine Editorial Team:   “This study, which includes data from the first 20,000 participants sequenced through the HKGP, provides initial insights on the actionable impact of genomic medicine in Hong Kong, and it introduces a blueprint for establishing precision medicine initiatives.”    The study has also received international recognition. Professor Zornitza Stark, Murdoch Children's Research Institute (MCRI), Melbourne, Victoria, Australia, opined:    “Although many national genomic projects publish ambitious plans, manuscripts describing results are few and far between. The HKGP is to be commended on the breadth and quality of the analysis. Undoubtedly, the project will contribute significantly to evidence generation and capacity building in Hong Kong, as well as make a major contribution globally.” Key impact highlights:   🔬 Applying European-based reference standards would have omitted 38 clinically important genes, under-recognised SCN5A and DSG2 enrichment, and highlighted differences in pharmacogenomic allele frequencies relevant to local prescribing.   🧬 A 25% diagnostic yield, 31% novel pathogenic variant rate, and identification of complex variants often missed by targeted approaches highlight the clinical value of whole-genome sequencing.   💊 Among diagnosed patients, 88% experienced potential changes in clinical management; approximately 900,000 prescriptions annually in Hong Kong could benefit from pharmacogenomic-informed prescribing; and expanded carrier screening increased detection rates from 48% to 65%.   🔎The findings underscore the importance of population-specific genomic resources to support equitable and accurate precision medicine.   Looking ahead to 2030, HKGI aims to reach 100,000 – 120,000 genomes, deepening ultra-rare variant discovery, refining PRS for Chinese populations, and integrating precision medicine into routine care.   We extend our sincere gratitude to all participants, collaborators, partnering centres and multidisciplinary teams who made this publication possible. 🙏   📝Read research briefing: https://lnkd.in/e-VsqpcS 📄Read the full paper: https://lnkd.in/gub8fXX4 {hashtag|\#|HKGI} {hashtag|\#|HKGP} {hashtag|\#|GenomeProject} {hashtag|\#|PrecisionMedicine} {hashtag|\#|GenomicMedicine} {hashtag|\#|NatureMedicine} {hashtag|\#|ScientificResearch}

【🌐 Discover the New Website of the Hong Kong Genome Institute!】 We are excited to share that our newly redesigned website is now live! It serves as a dynamic, seamless platform where you can explore genomics through interactive content, follow the Hong Kong Genome Project, access our latest research and clinical findings, and stay informed on our current news and events. 🔎 Key Sections to Explore: 💡 Discover Genomics Interactive pages with engaging visuals and animations that make genomic concepts accessible and easy to understand. 🧬 The Hong Kong Genome Project  Comprehensive project updates and connections to patient support groups dedicated to building a collaborative genomic medicine community. 🔬 Research & Innovation A dedicated space featuring significant clinical findings and technical papers, highlighting the latest advancements in genomics. 📰 Media Centre Latest news, press releases, media coverage, and event highlights, along with our official social media channels for ongoing updates and life‑changing stories. ✨Visit our new website today to discover more insights: www.hkgi.org {hashtag|\#|HKGI} {hashtag|\#|HKGP} {hashtag|\#|HongKongGenomeInstitute} {hashtag|\#|GenomicMedicine} {hashtag|\#|GenomeProject} {hashtag|\#|DigitalExperience} {hashtag|\#|WebsiteLaunch}

【Join the HKGI Graduate Internship Programme 2026! 🚀】   Ignite your passion for genomic medicine and get ready to launch your career in healthcare innovation!   The HKGI Graduate Internship Programme 2026 offers fresh graduates hands-on experience, structured learning, and cross-functional exposure by working alongside our professional teams. You will develop both technical and professional skills, building a strong foundation for a meaningful career in genomics and the broader healthcare sector.   🌟 Opportunities are available in:   • Medical & Scientific Branch  • Technology & Innovation Branch • Corporate Governance & Compliance • Finance & Procurement    Step forward and start your journey as our Graduate Intern.🎓💡   🔗 Action now: https://lnkd.in/gmsBrpTY {hashtag|\#|HKGI} {hashtag|\#|HKGP} {hashtag|\#|HongKongGenomeInstitute} {hashtag|\#|GenomicMedicine} {hashtag|\#|GenomeProject} {hashtag|\#|Careers} {hashtag|\#|GraduateProgramme} {hashtag|\#|Internship2026}

【Be Inspired: Culture Clash - Integrating Precision Genomic Medicine into an American Healthcare System】 Sharing knowledge and experience is the key to accelerating the development of genomic medicine. At HKGI, we continue to foster exchanges and collaborations.    One of our key initiatives is the partnership with the Asia Pacific Society of Human Genetics (APSHG) to co-host the “Distinguished Scholar Series”, which provides a platform for clinicians, scientists and researchers to share their work and perspectives. In the latest session, Professor Stephen Meyn shared insights on the practical challenges and opportunities in implementing precision genomic medicine within the American healthcare system, highlighting critical considerations for clinical practice. 🎤Topic: Culture Clash: Integrating Precision Genomic Medicine into an American Healthcare System 👨‍⚕️Speaker: Prof Stephen Meyn, Professor in the Division of Genetics & Metabolism, Department of Pediatrics, University of Wisconsin–Madison, and Director of the UW NORD Center of Excellence for Rare Diseases  🎙️Moderator: Dr Hon-Yin Brian Chung, Chief Executive Officer of HKGI and Immediate Past President of APSHG ➡️Watch the seminar here: https://lnkd.in/ef9UqQzB View the full collection of the Distinguished Scholar Series: https://lnkd.in/eUR32qSZ Explore more about HKGI and APSHG:  HKGI: https://hkgi.org APSHG: https://www.apshg.info {hashtag|\#|HKGI} {hashtag|\#|HKGP} {hashtag|\#|HongKongGenomeInstitute} {hashtag|\#|GenomicMedicine} {hashtag|\#|GenomeProject} {hashtag|\#|Collaboration} {hashtag|\#|KnowledgeExchange} {hashtag|\#|Innovation} {hashtag|\#|APSHG} {hashtag|\#|AsiaPacificSocietyOfHumanGenetics}

【AI Applications for Advancing Genetic Diagnosis in Neuro-developmental Disorders】 To connect medical professionals in genetics and genomics, we have been organising a series of thematic seminars under the GENE Club — a platform for clinicians, scientists, and researchers to exchange knowledge, foster collaboration, and nurture excellence in genomic medicine. In the latest session, we were delighted to welcome Dr Wei Ma and Ms Dream Chan, who shared cases from the Hong Kong Genome Project ({hashtag|\#|HKGP}) and demonstrated how AI is supporting clinicians in decoding complex genomic data, uncovering genetic causes of conditions such as autism and intellectual disability, and improving diagnostic pathways in Hong Kong. 🧬💡 🎤 Topic: AI Applications for Advancing Genetic Diagnosis in Neuro-developmental Disorders 🧑🏻‍🔬Speakers:  Dr Wei Ma Lead Scientist II (Genome Diagnostics and Precision Health), HKGI Ms Dream Chan Senior Research Assistant (Genome Curation), HKGI 🎙️ Moderator:  Dr Hon-Yin Brian Chung Chief Executive Officer, HKGI 📽️ Watch the seminar here: https://lnkd.in/gH-PQvtT   {hashtag|\#|HKGI} {hashtag|\#|HKGP} {hashtag|\#|HongKongGenomeInstitute} {hashtag|\#|GenomicMedicine} {hashtag|\#|GenomeProject} {hashtag|\#|GENEClub} {hashtag|\#|ArtificialIntelligence} {hashtag|\#|KnowledgeSharing}

【Applying Genomic Medicine to Kidney Diseases】   We are glad to share a feature interview with Dr Becky Ma by GeneOnline. Dr Ma is a recipient of the “Research Excellence Grants in Genomic Medicine” that we co-organise annually with the Hong Kong Academy of Medicine (HKAM).    As a specialist in nephrology, Dr Ma explained in the interview how whole genome sequencing (WGS) can enhance the detection of hereditary and rare kidney diseases, enabling more accurate diagnoses and patient‑centred clinical decisions. The conversation offered valuable insights into how genomic medicine is reshaping the diagnosis and management of kidney conditions.🧬   We remain committed to empowering clinicians and researchers in applying genomics for better patient outcomes and advancing precision healthcare globally. 🌍   🔗 Read the full interview: EN: https://lnkd.in/gbTwx59G TC: https://lnkd.in/g2JrQtMU   {hashtag|\#|HKGI} {hashtag|\#|HKGP} {hashtag|\#|GenomicMedicine} {hashtag|\#|Nephrology} {hashtag|\#|ResearchExcellence} {hashtag|\#|WholeGenomeSequencing}